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Accelrys software discovery studio visualizer v3.0
Software Discovery Studio Visualizer V3.0, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/discovery+studio+visualize+v3%2E0+software/software+discovery+studio+visualizer+v3+0/pmc10608285-153-10-14
Average 90 stars, based on 1 article reviews
software discovery studio visualizer v3.0 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Dopamine release and molecular modeling study of some coumarin derivatives.
Article Snippet: 4-aryl-2-amino-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-3-carbonitrile (1), 4-aryl-2-oxo-6-(4hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-3-carbonitriles (2a–2c), 3-(6-aryl-1,2,5,6tetrahydro-2-thioxopyrimidin-4-yl)-4-hydroxy-2H-chromen-2-one (3a, 3b) and pyrazol-3-yl-4-hydroxycoumarin derivatives (4a–4c, 5, 6a, 6b, 7a, 7b, and 8a–8c) were prepared in order to measure their % change dopamine release in comparison to amphetamine as reference, using PC-12 cells in different concentrations.. In addition, the molecular modeling study of the compounds into 3BHH receptor was also demonstrated.. The calculated inhibition constant (ki) implemented in the AutoDock program revealed identical correlation with the experimental results to that obtained binding free energy (DGb) as both parameters revealed reasonable correlation coefficients (R) being 0.51 involving 10 compounds; (1, 2b, 2c, 3a, 3b, 4a, 4b, 6a, and 8c).

Ligand Binding Assay:

Article Title: Dopamine release and molecular modeling study of some coumarin derivatives.
Article Snippet: 4-aryl-2-amino-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-3-carbonitrile (1), 4-aryl-2-oxo-6-(4hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-3-carbonitriles (2a–2c), 3-(6-aryl-1,2,5,6tetrahydro-2-thioxopyrimidin-4-yl)-4-hydroxy-2H-chromen-2-one (3a, 3b) and pyrazol-3-yl-4-hydroxycoumarin derivatives (4a–4c, 5, 6a, 6b, 7a, 7b, and 8a–8c) were prepared in order to measure their % change dopamine release in comparison to amphetamine as reference, using PC-12 cells in different concentrations.. In addition, the molecular modeling study of the compounds into 3BHH receptor was also demonstrated.. The calculated inhibition constant (ki) implemented in the AutoDock program revealed identical correlation with the experimental results to that obtained binding free energy (DGb) as both parameters revealed reasonable correlation coefficients (R) being 0.51 involving 10 compounds; (1, 2b, 2c, 3a, 3b, 4a, 4b, 6a, and 8c).



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90
Accelrys software discovery studio visualizer v3.0
Software Discovery Studio Visualizer V3.0, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/discovery+studio+visualize+v3%2E0+software/software+discovery+studio+visualizer+v3+0/pmc10608285-153-10-14
Average 90 stars, based on 1 article reviews
software discovery studio visualizer v3.0 - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Accelrys discovery studio visualize v3.0 software
Discovery Studio Visualize V3.0 Software, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/discovery+studio+visualize+v3%2E0+software/discovery+studio+2+5/pm21871512-56-15-21
Average 90 stars, based on 1 article reviews
discovery studio visualize v3.0 software - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

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